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OverviewTylenol Arthritis Pain Caplets are multi layered for extended pain relief. The first layer dissolves quickly to provide fast pain relief while the second layer dissolves slowly for extended pain relief. Since osteoarthritis, the most common form of arthritis, is primarily a problem of pain and not inflammation, medical experts recommend that pain relief be the primary goal of drug therapy. Acetaminophen, the medicine in Tylenol, is the preferred first-line drug therapy for the pain of osteoarthritis. In a major clinical study, Tylenol relieved osteoarthritis pain as effectively as nonprescription and even prescription doses of ibuprofen.