OverviewTylenol* Arthritis Pain Extended Relief offers the proven combination of strength and safety in an extended-relief form. Since osteoarthritis, the most common form of arthritis, is primarily a problem of pain and not inflammation, medical experts recommend that pain relief be the primary goal of drug therapy. Acetaminophen, the medicine in Tylenol, is the preferred first-line drug therapy for the pain of osteoarthritis. In a major clinical study, Tylenol relieved osteoarthritis pain as effectively as nonprescription and even prescription doses of ibuprofen. No other over-the-counter pain reliever has been proven to work better on arthritis pain than the medicine in Tylenol Arthritis Pain. And, used as directed, Tylenol Arthritis Pain is the safest type of pain reliever you can buy.